Iím to apply it to my whole face, once a day. After two hours I can apply a moisturizer and sunscreen but no makeup. My doctor said to put it on at night, before I went to bed. I decided to keep it to days, I have dry eyes and put moisturizing drops in them at night. I didnít want to risk getting the 5-FU in my eyes while I sleep. SoÖ itís no makeup to work. Most of my coworkers already knew my situation. They were very supportive. My Director even said I could do some work from home if I needed to.